The Inside Scoop On “Purified Omega 7″

Omega 7 Fatty Acid Health Benefits: ‘Discover the new “good” fat’

After hearing and maybe even experiencing the benefits of Omega 7 from plant sources like sea buckthorn, the truth about Purified Omega 7 Fatty Acids is starting to reach consumers in the US and around the world. Mentioned by Drs. Oz & Roizen in their popular syndicated YOU Docs columns for their remarkable cardiovascular and weight management benefits, consumers are seeing this rare and powerful “MUFA” (or Monounsaturated Fat) more and more in the media and in clinical trial results across the country.

Omega 7 Fatty Acid (or “Palmitoleic Acid”) can be found naturally in both plant and animal sources, including (1) macadamia nuts (2) sea buckthorn, and (3) fish oil. In nature, unfortunately, Palmitoleic Acid is always found conjoined with Palmitic acid. One is a monunsaturated fat with beneficial health effects. The other is a saturated fatty acid with negative health effects.

For best results, it’s very important to stress that Omega 7  be purified. Other formulations of Omega 7 on the market, including those with sea buckthorn, may contain upwards of 30% of Palmitic Acid, a saturated fatty acid that has been shown to have negative health effects.

The breakthrough is in the distillation of the “good” fatty acids

The “Purified Omega 7 Breakthrough” is in the purification and distillation of this amazing fatty acid — essentially you’re getting more of the “good” fatty acids.

Provinal™ Purified Omega 7 fatty acids, which are derived from fish oil (anchovy to be exact), set the standard for purity to remove saturated fatty acids and express high levels of palmitoleic acid (C16:1n7), which has great cardiovascular benefits in that it has been clinically shown to reduce C-reactive protein (CRP), reduce triglycerides and lousy (LDL) cholesterol, as well as increase good (HDL) cholesterol.

Purified Omega 7 Breakthrough: Why your Omega 7 should be “purified”

Regarding other formulations of Omega 7 that are not purified, that still contain palmitic acid, if you click on the WHO it brings up this listing Palmitic Acid in the same category of Increased Risk of  Developing Cardiovascular Disease Risk as Transfatty Acids.

Omega 7

According to this WHO table, palmitic Acid is in the same category as transfatty acids

Source: World Health Organization (WHO): Disease-specific recommendations 

Another way of looking at this table is that there is more convincing data on Palmitic Acid increasing the Risk of Cardiovascular Disease than dietary cholesterol. The World Health Organization (WHO) places palmitic acid in the same risk category as transfatty acids. How much transfat would you like in your supplements?

Dr. Michael Roizen: “The Benefits of Purified Omega 7”

In this 4-minute video, Dr. Michael F. Roizen, Chairman of the Wellness Institute of The Cleveland Clinic, talks about atherosclerosis, its causes and consequences: heart disease, stroke, memory loss, impotence, and wrinkling. He also shares how purified Omega 7 (palmitoleic acid) can potentially help in the fight against diabetes, metabolic syndrome, and atherosclerosis. This is exciting news because Purified Omega 7 “antagonizes” all three because it has been shown to decrease insulin resistance, decrease hepatic fat accumulation, and decrease inflammation – with no known side effects.



In the Media: What Drs. Oz & Roizen are saying about Purified Omega 7

Newspapers across the country published an article by Drs. Oz & Roizen about “5 Health breakthroughs you should know about.” One of them, actually the first one, was about Purified Omega 7 (Palmitoleic Acid). Here is an excerpt from the article:

Discover the new good fat, purified Omega 7

By Drs. Oz & Roizen, the YOU Docs

The “new” good fat! You’ve already heard plenty about DHA, the great-for-you omega-3 fatty acid in fatty fish and algae or fish-oil capsules.

Now, research from Harvard Medical School, the Cleveland Clinic (where Dr. Mike is Chief Wellness Officer) and universities in Hawaii and Japan that omega-7 fatty acids found in purified palmitoleic acid have amazing powers, too.

They squelched heart-threatening LDL cholesterol and triglycerides, boosted ticker-friendly HDLs, decreased fatty liver and improved cells’ ability to take in blood sugar in several well-designed studies.

Our take: Four studies are more than four times better than one, but we need more human trials before recommending omega-7s unconditionally. But we’re intrigued — enough so that at least Dr. Mike is taking 200 milligrams of purified omega-7 in capsule form along with the 900 milligrams of DHA we each take daily. (Always tell your doc about the supplements you take!)

Clinical Trials: The research behind Purified Omega 7 (Palmitoleic Acid)

To help you better understand why they might say this, here is a list of the research articles that they are referencing with a short interpretation of each one.

1. The Harvard Study

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Foundational study that showed that out of 400 fatty acids screened that palmitoleic acid was most active in regulating lipid metabolism. Showed Omega 7 inhibits SCD1 and positively regulated insulin action and inhibited hepatic steatosis.

This same group in December 2011 studied Omega 7 levels in humans and showed, in the study below this one, that it prevented the development of Type 2 diabetes in a population of over 3,000 patients.

Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults

Follow-up work from Harvard group above, along with NIH and Seattle research centers. Extremely significant study because of the volume of human-related cases that confirmed the importance of Omega 7 and its broad pharmacologic effects. Authors measured trans-palmitoleate because it exclusively comes from dairy sources and therefore is not confounded by endogenous production of C16:1.


2. The Cleveland Clinic Study

Effects of Palmitoleic Acid on HDL levels and Cholesterol Deposition in Apo-E Mice

Standard animal model used in drug development. This study was the first, and only to date, to look at the effect of C16:1 to inhibit plaque formation. Plaque reduction was dramatic, with virtual absence of atheroma at the aortic root in affected animals. Also, effect was seen across the entire population, not just in a few select animals. Effects on plaque development were double that seen for rosuvastatin, the most potent statin. Study was repeated because of unbelief and results were similar. HDL levels increased 85% in first study and ~40% in second. Unsure as to this being “cause & effect” with less plaque. Could be more of an anti-inflammatory mechanism or macrophage inhibition (i.e., TNF, etc).


3. The Hawaii & Virginia Study

Serum Lipid Effects of a High-Monounsaturated Fat Diet on Macadamia Nuts

Study showed significant declines in cholesterol and LDL levels. Also, significant declines in TG levels of 16%. Significant difference between Omega 7 and Lovaza is that LDL is NOT raised.


4. The Japanese Study

Chronic Administration of Palmitoleic Acid Reduces Insulin Resistance and Hepatic Lipid Accumulation in KK-Ay Mice with Genetic Type 2 Diabetes

Extremely significant and elegant study. Was first to administer Omega 7 directly, instead of assessing correlations of Omega 7 from dietary or endogenously-created sources. Mouse model used was genetically-manipulated mice to automatically develop Type 2 diabetes. Study showed Omega 7 reduced weight gain, improved insulin sensitivity, reduced hepatic steatosis, reduced TGs, inhibited translational production of TNF-alpha, reduced resistin levels, inhibited FAS and SCD1. Basically, corroborated earlier work by other investigators on the multifactorial and broad mechanisms of action of this fatty acid. Unsure as to correlation of mouse dose with humans – not been studied yet, however, when compared with TG effects with another study in the identical animal model, Omega 7 was shown to have 5x the potency of EPA.

To Sum Up:

Purified Omega 7 is better.

In the video above, Dr. Roizen puts purified Omega 7 into perspective: “This could have a huge benefit for our populations as a whole because metabolic syndrome, insulin resistance, and diabetes are big things we need to tackle for us to be more competitive for jobs, and the United States to be more competitive as a society.

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* Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Always consult your doctor before taking any dietary supplements.